Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation
نویسندگان
چکیده
منابع مشابه
Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management
The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining...
متن کاملPlatelet-Rich Plasma: Support for Its Use in Wound Healing
Previous topical growth factor studies have shown that recombinant human platelet-derived growth factor-BB isomer (rhPDGF-BB) is an efficacious treatment of chronic diabetic foot ulceration. A newer treatment, autologous platelet-rich plasma (PRP), represents a greater similarity to the natural healing process as a composite of multiple growth factors, is safe due to its autologous nature, and ...
متن کاملEffects of Platelet Rich Plasma (PRP) and Platelet Rich Growth Factor (PRGF®)on the Wound Healing of Distal Part of Limbs in Horses
Objectives- To evaluate the efficacy of platelet rich- plasma (PRP) and plasma rich-growth factor (PRGF®) on the wound healing on distal aspect of horses limbs. Design- Experimental study Animals - Four mixed- breed adult horses, 13 to 21 years of age and weighting 381 ±85 kg Procedures- The Limbs of each horse were treated with PRP, PRGF®, Silver Sulfa diazin and one limb received no treatment...
متن کاملPlatelet-rich plasma and platelet-derived lipid factors induce different and similar gene expression responses for selected genes related to wound healing in rat dermal wound environment
Although platelet-rich plasma (PRP) is the plasma fraction that contains higher levels of platelet-sequestered proteins such as growth factors and chemokines, it is also abundant in bioactive lipids whose role in wound healing has not been well characterized. This study provides a preliminary evaluation for the effect of the lipid component of PRP on selected genes related to wound healing. Spr...
متن کاملIntervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres.
This study evaluated the regenerative effects of platelet-rich plasma (PRP) for the degenerated intervertebral disc (IVD) in vivo. After induction of IVD degeneration in rabbits, we prepared PRP by centrifuging blood obtained from these rabbits. These PRP were injected into the nucleus pulposus (NP) of the degenerated IVDs after impregnation into gelatin hydrogel microspheres that can immobiliz...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2021
ISSN: 1449-1907
DOI: 10.7150/ijms.51060